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Lyon Daughters Lecture Series

 

About the Lyon Daughters Lecture

 

    Since 1992, the Rochester Academy of Medicine and the Lyon family have sponsored the Annual Lyon Daughters Lecture. This is a series of lectures that explore ethical issues of health care that appeal to the general public as well as to physicians. The lecture series was the idea of Allis Van Voorhis D'Amanda, granddaughter of Carolyn and Edmund Lyon. The lectures are held in the Lyon home which the Lyon's three daughters gave to the Academy in 1938. The daughters, Elzabeth Lyon Kidd born in 1898, the twins, Carolyn Lyon Remington and Linda Lyon Van Voorhis, born in 1902, inherited their parent's sense of civic pride, philanthropy and responsibility. It seems appropriate to honor these ladies in a way that would expand the medical educational activities that are one of the Academy's missions and reflect the humanitarian and cultural ideals of the Lyon family.

 

The 2008 Lyon Daughters Lecture will be:

Alzheimer's Disease: The Crux of Growing Old
Inevitable or Preventable?


Berislav V. Zlokovic, M.D., Ph.D.

Berislav V. Zlokovic, M.D., Ph.D. is Dean’s Professor and Professor of Neurosurgery & Neurology Director, Center for Neurodegenerative and Vascular Brain Disorders; Director, Frank P. Smith Laboratories for Neuroscience and Neurosurgical Research; Associate Chairman for Neurosurgery, University of Rochester Medical Center.

Every once in a while a scientist’s work fundamentally changes his peer’s views. Such is the case of the recent findings of Dr. Berislav Zlokovic. Much of the work by Dr. Zlokovic, who is known internationally for his work on stroke as well as Alzheimer’s, focuses on the crucial role of blood vessels. He has shown that blood circulation and clearance at the blood-brain barrier play a key role in ridding the brain of the toxic amyloid beta that attacks the brains of Alzheimer’s patients.


His team has identified much of the molecular machinery that allows amyloid beta to sidestep the body’s safeguard and accumulate in the brain. As a result of this work, Dr. Zlokovic has suggested several strategies for preventing or lowering amyloid-beta accumulation by influencing the body’s ability both to clear it from the brain and to prevent its reentry from the blood stream. Dr. Zlokovic’s team has also discovered a link between vascular-restricted genes in brain capillaries and small brain arteries and dysfunction in the blood vessels of people with Alzheimer’s disease. When they restored the effects of these genes, they noticed growth of new blood vessels, reduction in the death of cells, improvement in the clearance of amyloid-beta at the blood-brain barrier, and improved blood flow responses to brain activation.
 

His recent accomplishments have earned him a MERIT Award from the NIA, the Javits Award form the NINDS, awards form the NHLBI, and one of the inaugural ISOA/Elan awards for new drug discovery for Alzheimer’s disease.


This evening, Dr. Zlokovic will present an overview of the current understanding of Alzheimer’s disease: clinical presentation, epidemiology, pathology, pathogenesis, and available forms of treatment. He will present data generated in his laboratory showing the role of blood-brain barrier in the evolution of, and
the causation of, neurodegenerative disorders. Dr. Zlokovic will also address the ethical issues pertinent to the prevention and treatment of Alzheimer’s disease.
 

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PAST PRESENTATIONS OF THE LYON DAUGHTERS LECTURE

2007

"Cochlear Implants, Cool or Not So Cool"

Irene W. Leigh, Ph.D.

Professor, Department of Psychology, Gallaudet University.

John B. Christiansen, Ph.D.

Professor, Department of Sociology of Gallaudet University. Dr. Christiansen is co-author, along with Dr. Leigh, of the book Cochlear Implants in Children: Ethics and Choices.

2006

"On the Take: Commercial Influences on Medical Practice"

Jerome P. Kassirer, M.D.

Distinguished Professor, Tufts University school of Medicine and adjunct professor of Medicine and Bioethics, Case Western Reserve University School of Medicine.

2005

"Maternal-State Conflicts: Judging Drug-Using Pregnant Women."

Lynn M. Paltrow, J.D.

Executive Director and Founder of National Advocates for Pregnant Women (NAPW)

2004

"More Than a State of Mind: Ethics and Severe Brain Injury"

Joseph Fins, M.D.

Director of Medical Ethics at the Cornell campus of New York Presbyterian Hospital and Professor of Medicine, Professor of Public Health and Professor of Medicine in Psychiatry at the Weill Medical College of Cornell University.

2003

Who Owns Life? and Other Controversies in Stem Cell Research

Glenn McGee, Ph.D.

Associate Director for Education & Senior Fellow, Center for Bioethics & professor of Bioethics, Philosophy and History & Sociology of Science, Department of Bioethics, University of Pennsylvania School of Medicine

2002

TAKE TWO ECHINACEA AND CALL ME IN THE MORNING. Should your physician prescribe complementary and alternative therapies?

Karen E. Adams, M.D.

Chairman, Ethics Committee of the American Medical Women's Association, Assistant professor of Ob/GYN at the Oregon Health & Science University

2001

HEALTH CARE: AT WHAT ENVIRONMENTAL COST? A New Frontier in Bioethics

Andrew L. Jameton, PhD

Philosopher /Professor of Preventive and Societal Medicine University of Nebraska Medical Center

2000

TAKING CONTROL OF YOUR PAIN: Empowerment, Advocacy and Intervention

Betty R. Ferrell, RN, PhD

Research Scientist, City of Hope Medical Center, Duarte, California

1999

SEEING VOICES: A JOURNEY INTO THE WORLD OF THE DEAF

Oliver Sacks, MD

Neurologist; Author, Awakenings and The Man Who Mistook His Wife for a Hat

1998

ANIMALS & HUMANS: BRIDGING THE GAP

Peter Singer, PhD

Founder of modern animal rights movement

Author, Animal Rights Ethicist and Professor, Monash University, Australia

1997

REPRODUCTIVE ETHICS: PERSONAL CHOICE vs SOCIETAL REGULATION Debate Format

John Robertson, JD, Professor & Chair, School of Law, University of Texas

Bonnie Steinbock, PhD, Professor & Chair, Department of Philosophy, University of Albany, SUNY

1996

PHYSICIAN ASSISTED SUICIDE: PRO & CON Debate Format

Dan W. Brook, PhD (PRO), Director of Center of Biomedical Ethics, Brozvn University Edmund D. Pellegrino, MD (CON), Director of Center for Clinical Bioethics, Georgetown University

1995

HUMAN GUINEA PIGS? THE ETHICS of RADIATION EXPERIMENTS in the COLD WAR

Ruth Macklin, PhD

Philosopher, Bioethicist & Professor, Albert Einstein College of Medicine of Yeshiva University

1994

GENETIC ENGINEERING: ITS PROMISE & ETHICAL CONCERNS

George J. Annas, JD, MPH

Professor & Chair of Health Law Department, Boston University School of Public Health

1993

THE OREGON HEALTH PLAN

John Kitzhaber, MD, Physician and Oregon State Senator

1992

CONTROLLING DEATH: POSSIBILITIES & LIMITS

Daniel Callahan, PhD, Cofounder and Director of the Hastings Center